IUBMB Enzyme Nomenclature


Accepted name: tau-protein kinase

Reaction: ATP + [tau-protein] = ADP + O-phospho-[tau-protein]

Other name(s): ATP:tau-protein O-hosphotransferase; brain protein kinase PK40erk; cdk5/p20; CDK5/p23; glycogen synthase kinase-3β; GSK; protein tau kinase; STK31; tau kinase; [tau-protein] kinase; tau-protein kinase I; tau-protein kinase II; tau-tubulin kinase; TPK; TPK I; TPK II; TTK

Systematic name: ATP:[tau-protein] O-phosphotransferase

Comments: Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 111694-09-8


1. Ishiguro, K., Ihara, Y., Uchida, T. and Imahori, K. A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau. J. Biochem. (Tokyo) 104 (1988) 319-321. [PMID: 2467901]

2. Lund, E.T., McKenna, R., Evans, D.B., Sharma, S.K. and Mathews, W.R. Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry. J. Neurochem. 76 (2001) 1221-1232. [PMID: 11181841]

3. Michel, G., Mercken, M., Murayama, M., Noguchi, K., Ishiguro, K., Imahori, K. and Takashima, A. Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells. Biochim. Biophys. Acta 1380 (1998) 177-182. [PMID: 9565682]

4. Aoki, M., Iwamoto-Sugai, M., Sugiura, I., Sasaki, C., Hasegawa, T., Okumura, C., Sugio, S., Kohno, T. and Matsuzaki, T. Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3β. Acta Crystallogr. D Biol. Crystallogr. 56 (2000) 1464-1465. [PMID: 11053853]

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