IUBMB Enzyme Nomenclature


Accepted name: low-density-lipoprotein-receptor kinase

Reaction: ATP + [low-density-lipoprotein receptor]-L-serine = ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine

Other name(s): ATP:low-density-lipoprotein-L-serine O-phosphotransferase; LDL receptor kinase; [low-density-lipoprotein] kinase; low-density lipoprotein kinase; low-density-lipoprotein receptor kinase (phosphorylating); STK7

Systematic name: ATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase

Comments: Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 107445-00-1


1. Kishimoto, A., Brown, M.S., Slaughter, C.A. and Goldstein, J.L. Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II. J. Biol. Chem. 262 (1987) 1344-1351. [PMID: 3100530]

2. Kishimoto, A., Goldstein, J.L. and Brown, M.S. Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein. J. Biol. Chem. 262 (1987) 9367-9373. [PMID: 3597414]

[EC created 1990 as EC, transferred 2005 to EC]

Return to EC 2.7.11 home page
Return to EC 2.7 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page