IUBMB Enzyme Nomenclature


Accepted name: protein-histidine pros-kinase

Reaction: ATP + protein L-histidine = ADP + protein Nπ-phospho-L-histidine

Other name(s): ATP:protein-L-histidine N-pros-phosphotransferase; histidine kinase (ambiguous); histidine protein kinase (ambiguous); protein histidine kinase (ambiguous); protein kinase (histidine) (ambiguous); HK2

Systematic name: ATP:protein-L-histidine Nπ-phosphotransferase

Comments: A number of histones can act as acceptor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 99283-67-7


1. Fujitaki, J.M., Fung, G., Oh, E.Y. and Smith, R.A. Characterization of chemical and enzymatic acid-labile phosphorylation of histone H4 using phosphorus-31 nuclear magnetic resonance. Biochemistry 20 (1981) 3658-3664. [PMID: 7196259]

2. Huebner, V.D. and Matthews, H.R. Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia. J. Biol. Chem. 260 (1985) 16106-16113. [PMID: 4066704]

[EC created 1989 as EC, transferred 2005 to EC]

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