IUBMB Enzyme Nomenclature


Accepted name: protein arginine kinase

Reaction: ATP + a [protein]-L-arginine = ADP + a [protein]-Nω-phospho-L-arginine

Other name(s): McsB

Systematic name: ATP:[protein]-L-arginine Nω-phosphotransferase

Comments: The enzyme, characterized from Gram-positive bacteria, is involved in the regulation of the bacterial stress response.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Fuhrmann, J., Schmidt, A., Spiess, S., Lehner, A., Turgay, K., Mechtler, K., Charpentier, E. and Clausen, T. McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR. Science 324 (2009) 1323-1327. [PMID: 19498169]

2. Elsholz, A.K., Turgay, K., Michalik, S., Hessling, B., Gronau, K., Oertel, D., Mader, U., Bernhardt, J., Becher, D., Hecker, M. and Gerth, U. Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis. Proc. Natl. Acad. Sci. USA 109 (2012) 7451-7456. [PMID: 22517742]

3. Schmidt, A., Trentini, D.B., Spiess, S., Fuhrmann, J., Ammerer, G., Mechtler, K. and Clausen, T. Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response. Mol. Cell. Proteomics 13 (2014) 537-550. [PMID: 24263382]

[EC created 2014]

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