IUBMB Enzyme Nomenclature


Accepted name: 2-phosphoglycerate kinase

Reaction: ATP + 2-phospho-D-glycerate = ADP + 2,3-diphospho-D-glycerate

Other name(s): pgk2 (gene name)

Systematic name: ATP:2-phosphoglycerate 3-phosphotransferase

Comments: The enzyme, found in a number of methanogenic archaeal genera, is involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant. Activity is stimulated by potassium ions.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Lehmacher, A., Vogt, A.B. and Hensel, R. Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus. FEBS Lett. 272 (1990) 94-98. [PMID: 2226838]

2. Lehmacher, A. and Hensel, R. Cloning, sequencing and expression of the gene encoding 2-phosphoglycerate kinase from Methanothermus fervidus. Mol. Gen. Genet. 242 (1994) 163-168. [PMID: 8159166]

[EC created 2019]

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