IUBMB Enzyme Nomenclature


Accepted name: ATP-polyphosphate phosphotransferase

Reaction: ATP + (phosphate)n = ADP + (phosphate)n+1

Other name(s): polyphosphate kinase 1; ppk1 (gene name); polyphosphate kinase (ambiguous); polyphosphoric acid kinase (ambiguous)

Systematic name: ATP:polyphosphate phosphotransferase

Comments: The enzyme is responsible for the synthesis of most of the cellular polyphosphate, using the terminal phosphate of ATP as substrate.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9026-44-2


1. Hoffmann-Ostenhof, O., Kenedy, J., Keck, K., Gabriel, O. and Schönfellinger, H.W. En neues Phosphat-übertragendes Ferment aus Hefe. Biochim. Biophys. Acta 14 (1954) 285. [PMID: 13172250]

2. Kornberg, A., Kornberg, S.R. and Simms, E.S. Metaphosphate synthesis by an enzyme from Escherichia coli. Biochim. Biophys. Acta 20 (1956) 215-227. [PMID: 13315368]

3. Muhammed, A. Studies on biosynthesis of polymetaphosphate by an enzyme from Corynebacterium xerosis. Biochim. Biophys. Acta 54 (1961) 121-132. [PMID: 14476999]

4. Ahn, K. and Kornberg, A. Polyphosphate kinase from Escherichia coli. Purification and demonstration of a phosphoenzyme intermediate. J. Biol. Chem. 265 (1990) 11734-11739. [PMID: 2164013]

5. Kumble, K.D., Ahn, K. and Kornberg, A. Phosphohistidyl active sites in polyphosphate kinase of Escherichia coli. Proc. Natl. Acad. Sci. USA 93 (1996) 14391-14395. [PMID: 8962061]

[EC created 1961, modified 2021]

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