Reaction: UTP + α-D-galactose 1-phosphate = diphosphate + UDP-α-D-galactose
For diagram of reaction click here.
Other name(s): galactose-1-phosphate uridylyltransferase; galactose 1-phosphate uridylyltransferase; α-D-galactose 1-phosphate uridylyltransferase; galactose 1-phosphate uridyltransferase; UDPgalactose pyrophosphorylase; uridine diphosphate galactose pyrophosphorylase; uridine diphosphogalactose pyrophosphorylase
Systematic name: UTP:α-D-hexose-1-phosphate uridylyltransferase
Comments: α-D-Glucose 1-phosphate can also act as acceptor, but more slowly.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9016-11-9
1. Isselbacher, K.J. A mammalian uridinediphosphate galactose pyrophosphorylase. J. Biol. Chem. 232 (1958) 429-444.
2. Kalckar, H.M. The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides. Biochim. Biophys. Acta 12 (1953) 250-264.
3. Lee, L., Kimura, A. and Tochikura, T. Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum. J. Biochem. (Tokyo) 86 (1979) 923-928. [PMID: 500588]
4. Lobelle-Rich, P.A. and Reeves, R.E. Separation and characterization of two UTP-utilizing hexose phosphate uridylyltransferases from Entamoeba histolytica. Mol. Biochem. Parasitol. 7 (1983) 173-182. [PMID: 6304512]