IUBMB Enzyme Nomenclature


Accepted name: phosphoenolpyruvate guanylyltransferase

Reaction: phosphoenolpyruvate + GTP = enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate

Other name(s): fbiD (gene name)

Systematic name: GTP:phosphoenolpyruvate guanylyltransferase

Comments: This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor, in mycobacteria. cf. EC, 2-phospho-L-lactate guanylyltransferase and EC, 3-phospho-(R)-glycerate guanylyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc PDB, CAS registry number:


1. Bashiri, G., Antoney, J., Jirgis, E.NM., Shah, M.V., Ney, B., Copp, J., Stuteley, S.M., Sreebhavan, S., Palmer, B., Middleditch, M., Tokuriki, N., Greening, C., Scott, C., Baker, E.N. and Jackson, C.J. A revised biosynthetic pathway for the cofactor F420 in prokaryotes. Nat. Commun. 10 (2019) 1558. [PMID: 30952857]

2. Braga, D., Last, D., Hasan, M., Guo, H., Leichnitz, D., Uzum, Z., Richter, I., Schalk, F., Beemelmanns, C., Hertweck, C. and Lackner, G. Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420. ACS Chem. Biol. 14 (2019) 2088-2094. [PMID: 31469543]

[EC created 2020]

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