Reaction: GTP + 6-carboxymethyl-3,5-dimethyl-4-hydroxypyridin-2-ol = guanylylpyridinol + diphosphate
Glossary: guanylylpyridinol = [4-(5′-guanylyloxy)-6-hydroxy-3,5-dimethylpyridin-2-yl]acetate
Other name(s): hcgB (gene name)
Systematic name: GTP:6-carboxymethyl-3,5-dimethyl-4-hydroxypyridin-2-ol guanylyltransferase
Comments: The enzyme, characterized from the archaeon Methanococcus maripaludis, participates in the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor of EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase (also known as [Fe]-hydrogenase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Fujishiro, T., Tamura, H., Schick, M., Kahnt, J., Xie, X., Ermler, U. and Shima, S. Identification of the HcgB enzyme in [Fe]-hydrogenase-cofactor biosynthesis. Angew. Chem. Int. Ed. Engl. 52 (2013) 12555-12558. [PMID: 24249552]
2. Bai, L., Fujishiro, T., Huang, G., Koch, J., Takabayashi, A., Yokono, M., Tanaka, A., Xu, T., Hu, X., Ermler, U. and Shima, S. Towards artificial methanogenesis: biosynthesis of the [Fe]-hydrogenase cofactor and characterization of the semi-synthetic hydrogenase. Faraday Discuss 198 (2017) 37-58. [PMID: 28294213]