Reaction: GTP + α-D-mannose 1-phosphate = diphosphate + GDP-mannose
For diagram click here.
Other name(s): GTPmannose-1-phosphate guanylyltransferase; PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase); GDP-mannose pyrophosphorylase; guanosine 5'-diphospho-D-mannose pyrophosphorylase; guanosine diphosphomannose pyrophosphorylase; guanosine triphosphate-mannose 1-phosphate guanylyltransferase; mannose 1-phosphate guanylyltransferase (guanosine triphosphate)
Systematic name: GTP:α-D-mannose-1-phosphate guanylyltransferase
Comments: The bacterial enzyme can also use ITP and dGTP as donors.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 37278-24-3
1. Munch-Peterson, A. Enzymatic synthesis and phosphorolysis of guanosine diphosphate mannose. Arch. Biochem. Biophys. 55 (1955) 592-593.
2. Preiss, J. and Wood, E. Sugar nucleotide reactions in Arthrobacter. I. Guanosinediphosphate mannose pyrophosphorylase: purification and properties. J. Biol. Chem. 239 (1964) 3119-3126.