IUBMB Enzyme Nomenclature


Accepted name: nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase

Reaction: nucleoside triphosphate + α-D-aldose 1-phosphate = diphosphate + NDP-hexose

Other name(s): NDP hexose pyrophosphorylase; hexose 1-phosphate nucleotidyltransferase; hexose nucleotidylating enzyme; nucleoside diphosphohexose pyrophosphorylase; hexose-1-phosphate guanylyltransferase; GTP:α-D-hexose-1-phosphate guanylyltransferase; GDP hexose pyrophosphorylase; guanosine diphosphohexose pyrophosphorylase; nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase; NTP:hexose-1-phosphate nucleotidyltransferase

Systematic name: NTP:α-D-aldose-1-phosphate nucleotidyltransferase

Comments: In decreasing order of activity, guanosine, inosine and adenosine diphosphate hexoses are substrates in the reverse reaction, with either glucose or mannose as the sugar.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37278-26-5


1. Verachtert, H., Rodriguez, P., Bass, S.T. and Hansen, R.G. Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues. J. Biol. Chem. 241 (1966) 2007-2013. [PMID: 5946626]

2. Hansen, R.G., Verachtert, H., Rodriguez, P. and Bass, S.T. GDP-hexose pyrophosphorylase from liver. Methods Enzymol. 8 (1966) 269-271.

[EC created 1972, modified 2004 (EC created 1972, incorporated 2004)]

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