IUBMB Enzyme Nomenclature


Accepted name: pantetheine-phosphate adenylyltransferase

Reaction: ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA

For diagram of reaction click here.

Other name(s): dephospho-CoA pyrophosphorylase; pantetheine phosphate adenylyltransferase; dephospho-coenzyme A pyrophosphorylase; 3'-dephospho-CoA pyrophosphorylase

Systematic name: ATP:pantetheine-4'-phosphate adenylyltransferase

Comments: The enzyme from several bacteria (e.g. Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC, glucosamine-1-phosphate N-acetyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9026-99-7


1. Hoagland, M.B. and Novelli, G.D. Biosynthesis of coenzyme A from phosphopantetheine and of pantetheine from pantothenate. J. Biol. Chem. 207 (1954) 767-773.

2. Novelli, G.D. Enzymatic synthesis and structure of CoA. Fed. Proc. 12 (1953) 675-682.

3. Martin, D.P. and Drueckhammer, D.G. Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase. Biochem. Biophys. Res. Commun. 192 (1993) 1155-1161. [PMID: 8389542]

4. Geerlof, A., Lewendon, A. and Shaw, W.V. Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli. J. Biol. Chem. 274 (1999) 27105-27111. [PMID: 10480925]

5. Izard, T., Geerlof, A., Lewendon, A. and Barker, J.J. Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli. Acta Crystallogr. D Biol. Crystallogr. 55 1999) 1226-1228. [PMID: 10329792]

[EC created 1961, modified 2002]

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