Reaction: nucleoside triphosphate + RNAn = diphosphate + RNAn+1
Other name(s): RNA nucleotidyltransferase (RNA-directed); RNA nucleotidyltransferase (RNA-directed); RNA-dependent ribonucleate nucleotidyltransferase; 3D polymerase; PB1 proteins; PB2 proteins; phage f2 replicase; polymerase L; Q-β replicase; phage f2 replicase; ribonucleic acid replicase; ribonucleic acid-dependent ribonucleate nucleotidyltransferase; ribonucleic acid-dependent ribonucleic acid polymerase; ribonucleic replicase; ribonucleic synthetase; RNA replicase; RNA synthetase; RNA transcriptase; RNA-dependent ribonucleate nucleotidyltransferase; RDRP; RNA-dependent RNA polymerase; RNA-dependent RNA replicase; transcriptase
Systematic name: nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Comments: Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9026-28-2
References:
1. August, J.T., Cooper, S., Shapiro, L. and Zinder, N.D. RNA phage induced RNA polymerase. Cold Spring Harbour Symp. Quant. Biol. 28 (1963) 95-97.
2. Haruna, J., Nozu, K., Ohtaka, Y. and Spiegelman, S. An RNA "Replicase" induced by and selective for a viral RNA: isolation and properties. Proc. Natl. Acad. Sci. USA 50 (1963) 905-911. [PMID: 14082356]
3. Weismann, C., Simon, L. and Ochoa, S. Induction by an RNA phage of an enzyme catalyzing incorporation of ribonucleotides into ribonucleic acid. Proc. Natl. Acad. Sci. USA 49 (1963) 407-414. [PMID: 13999778]