IUBMB Enzyme Nomenclature


Accepted name: molybdenum cofactor guanylyltransferase

Reaction: GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor

For diagram of reaction click here.

Glossary: molybdenum cofactor = MoCo = MoO2(OH)Dtpp-mP = {[(5aR,8R,9aR)-2-amino-4-oxo-6,7-bis(sulfanyl-κS)-1,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(dioxo)molybdate

Other name(s): MobA (gene name); MoCo guanylyltransferase

Systematic name: GTP:molybdenum cofactor guanylyltransferase

Comments: Catalyses the guanylation of the molybdenum cofactor. This modification occurs only in prokaryotes.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Lake, M.W., Temple, C.A., Rajagopalan, K.V. and Schindelin, H. The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis. J. Biol. Chem. 275 (2000) 40211-40217. [PMID: 10978347]

2. Temple, C.A. and Rajagopalan, K.V. Mechanism of assembly of the bis(molybdopterin guanine dinucleotide)molybdenum cofactor in Rhodobacter sphaeroides dimethyl sulfoxide reductase. J. Biol. Chem. 275 (2000) 40202-40210. [PMID: 10978348]

3. Guse, A., Stevenson, C.E., Kuper, J., Buchanan, G., Schwarz, G., Giordano, G., Magalon, A., Mendel, R.R., Lawson, D.M. and Palmer, T. Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA. J. Biol. Chem. 278 (2003) 25302-25307. [PMID: 12719427]

[EC created 2011]

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