IUBMB Enzyme Nomenclature


Accepted name: CMP-N,N'-diacetyllegionaminic acid synthase

Reaction: CTP + N,N'-diacetyllegionaminate = CMP-N,N'-diacetyllegionaminate + diphosphate

For diagram of reaction click here.

Glossary: legionaminate = 5,7-diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonate

Other name(s): CMP-N,N'-diacetyllegionaminic acid synthetase; neuA (gene name); legF (gene name)

Systematic name: CTP:N,N'-diacetyllegionaminate cytidylyltransferase

Comments: Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni. Involved in biosynthesis of legionaminic acid, a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates which may include lipopolysaccharide (LPS), capsular polysaccharide, pili and flagella.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Glaze, P.A., Watson, D.C., Young, N.M. and Tanner, M.E. Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila. Biochemistry 47 (2008) 3272-3282. [PMID: 18275154]

2. Schoenhofen, I.C., Vinogradov, E., Whitfield, D.M., Brisson, J.R. and Logan, S.M. The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors. Glycobiology 19 (2009) 715-725. [PMID: 19282391]

[EC created 2012]

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