Reaction: 2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate
For diagram of reaction click here.
Glossary: cyclic di-3',5'-adenylate = c-di-AMP = c-di-adenylate = cyclic-bis(3'→5') dimeric AMP
Other name(s): cyclic-di-AMP synthase; dacA (gene name); disA (gene name)
Systematic name: ATP:ATP adenylyltransferase (cyclizing)
Comments: Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signalling molecule . The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host’s cytosol, where it triggers a cytosolic pathway of innate immunity .
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number:
1. Witte, G., Hartung, S., Buttner, K. and Hopfner, K.P. Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates. Mol. Cell 30 (2008) 167-178. [PMID: 18439896]
2. Woodward, J.J., Iavarone, A.T. and Portnoy, D.A. c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science 328 (2010) 1703-1705. [PMID: 20508090]