IUBMB Enzyme Nomenclature


Accepted name: diadenylate cyclase

Reaction: 2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate

For diagram of reaction click here.

Glossary: cyclic di-3',5'-adenylate = c-di-AMP = c-di-adenylate = cyclic-bis(3'→5') dimeric AMP

Other name(s): cyclic-di-AMP synthase; dacA (gene name); disA (gene name)

Systematic name: ATP:ATP adenylyltransferase (cyclizing)

Comments: Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signalling molecule [1]. The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host’s cytosol, where it triggers a cytosolic pathway of innate immunity [2].

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number:


1. Witte, G., Hartung, S., Buttner, K. and Hopfner, K.P. Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates. Mol. Cell 30 (2008) 167-178. [PMID: 18439896]

2. Woodward, J.J., Iavarone, A.T. and Portnoy, D.A. c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science 328 (2010) 1703-1705. [PMID: 20508090]

[EC created 2013]

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