IUBMB Enzyme Nomenclature


Accepted name: ADP-D-ribose pyrophosphorylase

Reaction: ATP + D-ribose 5-phosphate = diphosphate + ADP-D-ribose

Other name(s): NUDIX5; NUDT5 (gene name); diphosphate—ADP-D-ribose adenylyltransferase; diphosphate adenylyltransferase (ambiguous)

Systematic name: ATP:D-ribose 5-phosphate adenylyltransferase

Comments: The human enzyme produces ATP in nuclei in situations of high energy demand, such as chromatin remodeling. The reaction is dependent on the presence of diphosphate. In its absence the enzyme catalyses the reaction of EC, ADP-ribose diphosphatase. cf. EC, ADP ribose phosphorylase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Wright, R.H., Lioutas, A., Le Dily, F., Soronellas, D., Pohl, A., Bonet, J., Nacht, A.S., Samino, S., Font-Mateu, J., Vicent, G.P., Wierer, M., Trabado, M.A., Schelhorn, C., Carolis, C., Macias, M.J., Yanes, O., Oliva, B. and Beato, M. ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. Science 352 (2016) 1221-1225. [PMID: 27257257]

[EC created 2016]

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