Reaction: CDP-diacylglycerol + myo-inositol = CMP + 1-phosphatidyl-1D-myo-inositol
For diagram click here.
Glossary: 1-phosphatidyl-1D-myo-inositol = PtdIns
Other name(s): CDP-diglyceride—inositol phosphatidyltransferase; phosphatidylinositol synthase; CDP-diacylglycerol-inositol phosphatidyltransferase; CDP-diglyceride:inositol transferase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase; CDP-DG:inositol transferase; cytidine diphosphodiglyceride-inositol phosphatidyltransferase; CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase; CDP-diglyceride-inositol transferase; cytidine diphosphoglyceride-inositol phosphatidyltransferase; cytidine diphosphoglyceride-inositol transferase
Systematic name: CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9027-01-4
References:
1. Bleasdale, J.E., Wallis, P., MacDonald, P.C. and Johnston, J.M. Characterization of the forward and reverse reactions catalyzed by CDP-diacylglycerol:inositol transferase in rabbit lung tissue. Biochim. Biophys. Acta 575 (1979) 135-147. [PMID: 41587]
2. Prottey, C. and Hawthorne, J.N. The biosynthesis of phosphatidic acid and phosphatidylinositol in mammalian pancreas. Biochem. J. 105 (1967) 379-392. [PMID: 4293959]
3. Salway, J.G., Harewood, J.L., Kai, M., White, G.L. and Hawthorne, J.N. Enzymes of phosphoinositide metabolism during rat brain development. J. Neurochem. 15 (1968) 221-226. [PMID: 4295616]
4. Takenawa, T. and Egawa, K. CDP-diglyceride:inositol transferase from rat liver. Purification and properties. J. Biol. Chem. 252 (1977) 5419-5423. [PMID: 18462]