IUBMB Enzyme Nomenclature


Accepted name: carboxyvinyl-carboxyphosphonate phosphorylmutase

Reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydroxyphosphinoyl)pyruvate + CO2

Systematic name: 1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)

Comments: catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 122799-57-9


1. Pollack, S.J., Freeman, S., Pompliano, D.L., Knowles, J.R. Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus. Eur. J. Biochem. 209 (1992) 735-743. [PMID: 1330557]

2. Anzai, H., Murakami, T., Imai, S., Satoh, A., Nagaoka, K., Thompson, C.J. Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus. J. Bacteriol. 169 (1987) 3482-3488. [PMID: 3611020]

[EC created 1999]

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