Reaction: UDP-N-acetyl-α-D-galactosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-α-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol
Other name(s): WecP; UDP-GalNAc:polyprenol-P GalNAc-1-P transferase; UDP-GalNAc:undecaprenyl-phosphate GalNAc-1-phosphate transferase
Systematic name: UDP-N-acetyl-α-D-galactosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-galactosaminephosphotransferase
Comments: The enzyme catalyses a step in the assembly of the repeating-unit of the O-antigen of the Gram-negative bacterium Aeromonas hydrophila AH-3. The enzyme shows no activity with UDP-N-acetyl-α-D-glucosamine (cf. EC 2.7.8.33, UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Merino, S., Jimenez, N., Molero, R., Bouamama, L., Regue, M. and Tomas, J.M. A UDP-HexNAc:polyprenol-P GalNAc-1-P transferase (WecP) representing a new subgroup of the enzyme family. J. Bacteriol. 193 (2011) 1943-1952. [PMID: 21335454]