IUBMB Enzyme Nomenclature

EC 2.8.3.18

Accepted name: succinyl-CoA:acetate CoA-transferase

Reaction: succinyl-CoA + acetate = acetyl-CoA + succinate

Other name(s): aarC (gene name); SCACT

Systematic name: succinyl-CoA:acetate CoA-transferase

Comments: In some bacteria the enzyme catalyses the conversion of acetate to acetyl-CoA as part of a modified tricarboxylic acid (TCA) cycle [3,5,6]. In other organisms it converts acetyl-CoA to acetate during fermentation [1,2,4,7]. In some organisms the enzyme also catalyses the activity of EC 2.8.3.27, propanoyl-CoA:succinate CoA transferase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Steinbuchel, A. and Muller, M. Anaerobic pyruvate metabolism of Tritrichomonas foetus and Trichomonas vaginalis hydrogenosomes. Mol. Biochem. Parasitol. 20 (1986) 57-65. [PMID: 3090435]

2. Sohling, B. and Gottschalk, G. Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri. J. Bacteriol. 178 (1996) 871-880. [PMID: 8550525]

3. Mullins, E.A., Francois, J.A. and Kappock, T.J. A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti. J. Bacteriol. 190 (2008) 4933-4940. [PMID: 18502856]

4. van Grinsven, K.W., van Hellemond, J.J. and Tielens, A.G. Acetate:succinate CoA-transferase in the anaerobic mitochondria of Fasciola hepatica. Mol. Biochem. Parasitol. 164 (2009) 74-79. [PMID: 19103231]

5. Mullins, E.A. and Kappock, T.J. Crystal structures of Acetobacter aceti succinyl-coenzyme A (CoA):acetate CoA-transferase reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases. Biochemistry 51 (2012) 8422-8434. [PMID: 23030530]

6. Kwong, W.K., Zheng, H. and Moran, N.A. Convergent evolution of a modified, acetate-driven TCA cycle in bacteria. Nat Microbiol 2 (2017) 17067. [PMID: 28452983]

7. Zhang, B., Lingga, C., Bowman, C. and Hackmann, T.J. A new pathway for forming acetate and synthesizing ATP during fermentation in bacteria. Appl. Environ. Microbiol. 87 (2021) e0295920. [PMID: 33931420]

[EC 2.8.3.18 created 2013, modified 2022]


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