IUBMB Enzyme Nomenclature


Accepted name: succinyl-CoA:acetate CoA-transferase

Reaction: succinyl-CoA + acetate = acetyl-CoA + succinate

Other name(s): aarC (gene name); SCACT

Systematic name: succinyl-CoA:acetate CoA-transferase

Comments: In acetic acid bacteria the enzyme, which is highly specific, catalyses the conversion of toxic acetate to acetyl-CoA [2,3]. In the hydrogenosomes of some trichomonads the enzyme catalyses the production of acetate [1].

Links to other databases: BRENDA, EXPASY, GTD, KEGG, CAS registry number:


1. Steinbuchel, A. and Muller, M. Anaerobic pyruvate metabolism of Tritrichomonas foetus and Trichomonas vaginalis hydrogenosomes. Mol. Biochem. Parasitol. 20 (1986) 57-65. [PMID: 3090435]

2. Mullins, E.A., Francois, J.A. and Kappock, T.J. A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti. J. Bacteriol. 190 (2008) 4933-4940. [PMID: 18502856]

3. Mullins, E.A. and Kappock, T.J. Crystal structures of Acetobacter aceti succinyl-coenzyme A (CoA):acetate CoA-transferase reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases. Biochemistry 51 (2012) 8422-8434. [PMID: 23030530]

[EC created 2013]

Return to EC 2.8.3 home page
Return to EC 2.8 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page