IUBMB Enzyme Nomenclature


Accepted name: propanoyl-CoA:succinate CoA transferase

Reaction: propanoyl-CoA + succinate = propanoate + succinyl-CoA

Other name(s): succinyl-CoA:propionate CoA-transferase; propionyl-CoA:succinyl-CoA transferase; ASCT; scpC (gene name)

Systematic name: propanoyl-CoA:succinate CoA transferase

Comments: The enzyme is most specific in Escherichia coli, where the preferred substrates are propanoyl-CoA and succinate. In other organisms, the enzyme uses acetyl-CoA at the same rate as propanoyl-CoA (cf. EC, succinyl-CoA:acetate CoA-transferase).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Allen, S. H., Kellermeyer, R. W., Stjernholm, R. L., and Wood, H. G. Purification and properties of enzymes involved in the propionic acid fermentation. J. Bacteriol. 87 (1964) 171-187. [PMID: 14102852]

2. Schulz, T.KF. and Kluytmans, J.H. Pathway of propionate synthesis in the sea mussel Mytilus edulis L. Comp. Biochem. Physiol. B. Comp. Biochem. 75 (1983) 365-372.

3. Haller, T., Buckel, T., Retey, J. and Gerlt, J.A. Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli. Biochemistry 39 (2000) 4622-4629. [PMID: 10769117]

4. van Grinsven, K.W., van Hellemond, J.J. and Tielens, A.G. Acetate:succinate CoA-transferase in the anaerobic mitochondria of Fasciola hepatica. Mol. Biochem. Parasitol. 164 (2009) 74-79. [PMID: 19103231]

5. Zhang, B., Lingga, C., Bowman, C. and Hackmann, T.J. A new pathway for forming acetate and synthesizing ATP during fermentation in bacteria. Appl. Environ. Microbiol. 87 (2021) e0295920. [PMID: 33931420]

[EC created 2022]

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