IUBMB Enzyme Nomenclature


Accepted name: S-methyl-1-thioxylulose 5-phosphate methylthiotransferase

Reaction: S-methyl-1-thio-D-xylulose 5-phosphate + glutathione = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione

Other name(s): 1-methylthioxylulose 5-phosphate sulfurylase (incorrect)

Systematic name: S-methyl-1-thio-D-xylulose 5-phosphate:glutathione methylthiotransferase

Comments: The enzyme, characterized from the bacterium Rhodospirillum rubrum, belongs to the cupin superfamily and contains a manganese ion. It participates in an anaerobic salvage pathway that restores methionine from S-methyl-5'-thioadenosine. The enzyme was assayed in vitro using L-dithiothreitol instead of glutathione.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Erb, T.J., Evans, B.S., Cho, K., Warlick, B.P., Sriram, J., Wood, B.M., Imker, H.J., Sweedler, J.V., Tabita, F.R. and Gerlt, J.A. A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis. Nat. Chem. Biol. 8 (2012) 926-932. [PMID: 23042035]

2. Warlick, B.P., Evans, B.S., Erb, T.J., Ramagopal, U.A., Sriram, J., Imker, H.J., Sauder, J.M., Bonanno, J.B., Burley, S.K., Tabita, F.R., Almo, S.C., Sweedler, J.S. and Gerlt, J.A. 1-methylthio-D-xylulose 5-phosphate methylsulfurylase: a novel route to 1-deoxy-D-xylulose 5-phosphate in Rhodospirillum rubrum, Biochemistry 51 (2012) 8324-8326. [PMID: 23035785]

3. Cho, K., Evans, B.S., Wood, B.M., Kumar, R., Erb, T.J., Warlick, B.P., Gerlt, J.A. and Sweedler, J.V. Integration of untargeted metabolomics with transcriptomics reveals active metabolic pathways. Metabolomics 2014 (2014) . [PMID: 25705145]

[EC created 2021]

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