Reaction: acetylsalicylate + H2O = salicylate + acetate
Other name(s): aspirin esterase; aspirin esterase; acetylsalicylic acid esterase; aspirin hydrolase
Systematic name: acetylsalicylate O-acetylhydrolase
Comments: Not identical with EC 184.108.40.206 (carboxylesterase), EC 220.127.116.11 (arylesterase), EC 18.104.22.168 (acetylcholinesterase) or EC 22.214.171.124 (cholinesterase). The activity of the liver cytosol enzyme is highest with acetyl esters of aryl alcohols, and thioesters are also hydrolysed; the microsomal enzyme also hydrolyses some other negatively charged esters, with highest activity on esters of salicylate with long-chain alcohols.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 87348-04-7
1. Ali, B. and Kaur, S. Mammalian tissue acetylsalicylic acid esterase(s): identification, distribution and discrimination from other esterases. J. Pharmacol. Exp. Ther. 226 (1983) 589-594. [PMID: 6875867]
2. Kim, D.-H., Yang, Y.-S. and Jakoby, W.B. Aspirin hydrolyzing esterases from rat liver cytosol. Biochem. Pharmacol. 40 (1990) 481-487. [PMID: 2383281]
3. White, K.N. and Hope, D.B. Partial purification and characterization of a microsomal carboxylesterase specific for salicylate esters from guinea-pig liver. Biochim. Biophys. Acta 785 (1984) 138-147. [PMID: 6704404]