IUBMB Enzyme Nomenclature


Accepted name: [Wnt protein] O-palmitoleoyl-L-serine hydrolase

Reaction: [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H2O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate

Glossary: (9Z)-hexadec-9-enoate = palmitoleoate

Other name(s): Notum

Systematic name: [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine acylhydrolase

Comments: The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC, [Wnt protein]-O-palmitoleoyl transferase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Kakugawa, S., Langton, P.F., Zebisch, M., Howell, S.A., Chang, T.H., Liu, Y., Feizi, T., Bineva, G., O'Reilly, N., Snijders, A.P., Jones, E.Y. and Vincent, J.P. Notum deacylates Wnt proteins to suppress signalling activity. Nature (2015) . [PMID: 25731175]

[EC created 2015]

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