Reaction: a sphingoid base 1-phosphate + H2O = a sphingoid base + phosphate
Other name(s): S1P phosphatase; sphingosine-1-phosphate phosphatase; long-chain base-1-phosphate phosphatase; dihydrosphingosine-1-phosphate phosphatase; LCB3 (gene name); YSR3 (gene name); SGPP1 (gene name); SGPP2 (gene name)
Systematic name: sphingoid base 1-phosphate phosphohydrolase
Comments: The enzyme specifically dephosphorylates long-chain sphingoid base phosphates such as sphingosine 1-phosphate, sphinganine 1-phosphate, and phytosphingosine 1-phosphate. It does not act on ceramide 1-phosphate, lysophosphatidic acids, or phosphatidic acids. cf. EC 3.1.3.4, phosphatidate phosphatase, EC 3.1.3.106, 2-lysophosphatidate phosphatase, and EC 3.1.3.113, phospholipid phosphatase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Mandala, S.M., Thornton, R., Tu, Z., Kurtz, M.B., Nickels, J., Broach, J., Menzeleev, R. and Spiegel, S. Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc. Natl. Acad. Sci. USA 95 (1998) 150-155. [PMID: 9419344]
2. Mao, C., Saba, J.D. and Obeid, L.M. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem. J. 342 Pt 3 (1999) 667-675. [PMID: 10477278]
3. Ogawa, C., Kihara, A., Gokoh, M. and Igarashi, Y. Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. J. Biol. Chem. 278 (2003) 1268-1272. [PMID: 12411432]
4. Giussani, P., Maceyka, M., Le Stunff, H., Mikami, A., Lepine, S., Wang, E., Kelly, S., Merrill, A.H., Jr., Milstien, S. and Spiegel, S. Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol. Cell Biol. 26 (2006) 5055-5069. [PMID: 16782891]