Reaction: a phospholipid + H2O = a lipid + phosphate
Other name(s): lipid phosphate phosphatase; type 2 phosphatidic acid phosphatase; PAP2; PLPP1 (gene name); PLPP2 (gene name); PLPP3 (gene name); PLPP4 (gene name)
Systematic name: phospholipid phosphohydrolase
Comments: The enzyme is a Mg2+-independent phosphatase that catalyses the dephosphorylation of a broad spectrum of glycerolipid and sphingolipid phosphate esters, including phosphatidate, lysophosphatidate, diacylglycerol pyrophosphate, sphingosine 1-phosphate, and ceramide 1-phosphate. cf. EC 3.1.3.4, phosphatidate phosphatase, EC 3.1.3.106, 2-lysophosphatidate phosphatase, EC 3.1.3.114, sphingoid-base-1-phosphate phosphatase, and EC 3.1.3.115, ceramide-1-phosphate phosphatase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Kai, M., Wada, I., Imai Si, Sakane, F. and Kanoh, H. Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase. J. Biol. Chem. 272 (1997) 24572-24578. [PMID: 9305923]
2. Hooks, S.B., Ragan, S.P. and Lynch, K.R. Identification of a novel human phosphatidic acid phosphatase type 2 isoform. FEBS Lett. 427 (1998) 188-192. [PMID: 9607309]
3. Roberts, R., Sciorra, V.A. and Morris, A.J. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. J. Biol. Chem. 273 (1998) 22059-22067. [PMID: 9705349]
4. Waggoner, D.W., Xu, J., Singh, I., Jasinska, R., Zhang, Q.X. and Brindley, D.N. Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction. Biochim. Biophys Acta 1439 (1999) 299-316. [PMID: 10425403]
5. Roberts, R.Z. and Morris, A.J. Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators. Biochim. Biophys Acta 1487 (2000) 33-49. [PMID: 10962286]
6. Zhao, Y., Kalari, S.K., Usatyuk, P.V., Gorshkova, I., He, D., Watkins, T., Brindley, D.N., Sun, C., Bittman, R., Garcia, J.G., Berdyshev, E.V. and Natarajan, V. Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J. Biol. Chem. 282 (2007) 14165-14177. [PMID: 17379599]
7. Tang, X., Benesch, M.G. and Brindley, D.N. Lipid phosphate phosphatases and their roles in mammalian physiology and pathology. J. Lipid Res. 56 (2015) 2048-2060. [PMID: 25814022]