Reaction: a ceramide 1-phosphate + H2O = a ceramide + phosphate
Other name(s): C1PP; C1P phosphatase
Systematic name: ceramide-1-phosphate phosphohydrolase
Comments: Ceramide 1-phosphate, produced by EC 2.7.1.138, ceramide kinase, is dephosphorylated in mammalian tissue. EC 3.1.3.113, phospholipid phosphatase, has been shown to catalyse this activity in vitro.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Shinghal, R., Scheller, R.H. and Bajjalieh, S.M. Ceramide 1-phosphate phosphatase activity in brain. J. Neurochem. 61 (1993) 2279-2285. [PMID: 8245978]
2. Boudker, O. and Futerman, A.H. Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane. J. Biol. Chem. 268 (1993) 22150-22155. [PMID: 8408075]
3. Waggoner, D.W., Gomez-Munoz, A., Dewald, J. and Brindley, D.N. Phosphatidate phosphohydrolase catalyzes the hydrolysis of ceramide 1-phosphate, lysophosphatidate, and sphingosine 1-phosphate. J. Biol. Chem. 271 (1996) 16506-16509. [PMID: 8663293]
4. Roberts, R., Sciorra, V.A. and Morris, A.J. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. J. Biol. Chem. 273 (1998) 22059-22067. [PMID: 9705349]
5. Brindley, D.N., Xu, J., Jasinska, R. and Waggoner, D.W. Analysis of ceramide 1-phosphate and sphingosine-1-phosphate phosphatase activities. Methods Enzymol. 311 (2000) 233-244. [PMID: 10563330]