Reaction: [pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate
Glossary: lipoyl group
Other name(s): pyruvate dehydrogenase phosphatase; phosphopyruvate dehydrogenase phosphatase; [pyruvate dehydrogenase (lipoamide)]-phosphatase; [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase
Systematic name: [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase
Comments: A mitochondrial enzyme associated with EC 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring), in the pyruvate dehydrogenase complex.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9073-70-5
References:
1. Linn, T.C., Pelley, J.W., Petit, F.H., Hucho, F., Randall, D.D. and Reed, L.J. α-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart. Arch. Biochem. Biophys. 148 (1972) 327-342. [PMID: 4401694]
2. Reed, L.J., Damuni, Z. and Merryfield, M.L. Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation. Curr. Top. Cell. Regul. 27 (1985) 41-49. [PMID: 3004826]