IUBMB Enzyme Nomenclature


Accepted name: 2,3-bisphosphoglycerate 3-phosphatase

Reaction: 2,3-bisphospho-D-glycerate + H2O = 2-phospho-D-glycerate + phosphate

Other name(s): MIPP1; 2,3-BPG 3-phosphatase

Systematic name: 2,3-bisphospho-D-glycerate 3-phosphohydrolase

Comments: This reaction is a shortcut in the Rapoport-Luebering shunt. It bypasses the reactions of EC [phosphoglycerate mutase (2,3-diphosphoglycerate-independent)] and directly forms 2-phospho-D-glycerate by removing the 3-phospho-group of 2,3-diphospho-D-glycerate [1]. The MIPP1 protein also catalyses the reaction of EC (multiple inositol-polyphosphate phosphatase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Cho, J., King, J.S., Qian, X., Harwood, A.J. and Shears, S.B. Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. Proc. Natl. Acad. Sci. USA 105 (2008) 5998-6003. [PMID: 18413611]

[EC created 2010]

Return to EC 3.1.3 home page
Return to EC 3.1 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page