IUBMB Enzyme Nomenclature


Accepted name: multiple inositol-polyphosphate phosphatase

Reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate

Other name(s): inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase; inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase; inositol tetrakisphosphate phosphomonoesterase; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase; MIPP

Systematic name: 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase

Comments: This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 116958-30-6


1. Cullen, P.J., Irvine, R.F., Drøbak, B.J. and Dawson, A.P. Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate. Biochem. J. 259 (1989) 931-933. [PMID: 2786415]

2. Craxton, A., Caffrey, J.J., Burkhart, W., Safrany, S.T. and Shears, S.B. Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase. Biochem. J. 328 (1997) 75-81. [PMID: 9359836]

[EC created 1992, modified 2002]

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