IUBMB Enzyme Nomenclature


Accepted name: carbonyl sulfide hydrolase

Reaction: carbonyl sulfide + H2O = hydrogen sulfide + CO2

Other name(s): COSase; COS hydrolase; cos (gene name)

Systematic name: carbonyl sulfide hydrogen-sulfide-lyase (decarboxylating)

Comments: The enzyme, characterized from the bacterium Thiobacillus thioparus, catalyses a step in the degradation pathway of thiocyanate. This activity is also catalysed by the archaeal EC, carbon disulfide lyase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Ogawa, T., Noguchi, K., Saito, M., Nagahata, Y., Kato, H., Ohtaki, A., Nakayama, H., Dohmae, N., Matsushita, Y., Odaka, M., Yohda, M., Nyunoya, H. and Katayama, Y. Carbonyl sulfide hydrolase from Thiobacillus thioparus strain THI115 is one of the β-carbonic anhydrase family enzymes. J. Am. Chem. Soc. 135 (2013) 3818-3825. [PMID: 23406161]

[EC created 2018]

Return to EC 3.13.1 home page
Return to EC 3.13 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page