Reaction: carbonyl sulfide + H2O = hydrogen sulfide + CO2
Other name(s): COSase; COS hydrolase; cos (gene name)
Systematic name: carbonyl sulfide hydrogen-sulfide-lyase (decarboxylating)
Comments: The enzyme, characterized from the bacterium Thiobacillus thioparus, catalyses a step in the degradation pathway of thiocyanate. This activity is also catalysed by the archaeal EC 22.214.171.124, carbon disulfide lyase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
1. Ogawa, T., Noguchi, K., Saito, M., Nagahata, Y., Kato, H., Ohtaki, A., Nakayama, H., Dohmae, N., Matsushita, Y., Odaka, M., Yohda, M., Nyunoya, H. and Katayama, Y. Carbonyl sulfide hydrolase from Thiobacillus thioparus strain THI115 is one of the β-carbonic anhydrase family enzymes. J. Am. Chem. Soc. 135 (2013) 3818-3825. [PMID: 23406161]