IUBMB Enzyme Nomenclature


Accepted name: keratan-sulfate endo-1,4-β-galactosidase

Reaction: Endohydrolysis of (1→4)-β-D-galactosidic linkages in keratan sulfate

Other name(s): endo-β-galactosidase (ambiguous); keratan sulfate endogalactosidase; keratanase; keratan-sulfate 1,4-β-D-galactanohydrolase

Systematic name: keratan-sulfate 4-β-D-galactanohydrolase

Comments: Hydrolyses the 1,4-β-D-galactosyl linkages adjacent to 1,3-N-acetyl-α-D-glucosaminyl residues. Also acts on some non-sulfated oligosaccharides, but only acts on blood group substances when the 1,2-linked fucosyl residues have been removed (cf. EC blood-group-substance endo-1,4-β-galactosidase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 55072-01-0


1. Fukuda, M.N. and Matsumara, G. Endo-β-galactosidase of Escherichia freundii. Purification and endoglycosidic action on keratan sulfates, oligosaccharides, and blood group active glycoprotein. J. Biol. Chem. 251 (1976) 6218-6225. [PMID: 135762]

[EC created 1984]

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