IUBMB Enzyme Nomenclature


Accepted name: exo-α-sialidase

Reaction: Hydrolysis of α-(2→3)-, α-(2→6)-, α-(2→8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates

Other name(s): neuraminidase; sialidase; α-neuraminidase; acetylneuraminidase

Systematic name: acetylneuraminyl hydrolase

Comments: The enzyme does not act on 4-O-acetylated sialic acids. endo-α-Sialidase activity is listed as EC, endo-α-sialidase. See also EC anhydrosialidase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9001-67-6


1. Schauer, R. Sialic acids. Adv. Carbohydr. Chem. Biochem. 40 (1982) 131-234.

2. Cabezas, J.A. Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase. Biochem. J. 278 (1991) 311-312. [PMID: 1883340]

[EC created 1961, modified 1999]

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