Reaction: Hydrolysis of terminal non-reducing α-D-arabinofuranoside residues in D-arabinans
Other name(s): exo-α-D-arabinofuranosidase; DgGH172a; DgGH172b; DgGH172c; NocGH172; MycGH172; ExoMA1
Systematic name: α-D-arabinofuranoside non-reducing end α-D-arabinofuranosidase (configuration-retaining)
Comments: The enzyme hydrolyses α-D-arabinofuranosides with (1,3)- and (1,5)-linkages in D-arabinan core structure of lipoarabinomannan and arabinogalactan of mycobacterial cell wall. cf. EC 3.2.1.55, non-reducing end α-L-arabinofuranosidase; cf. EC 3.2.1.224, D-arabinan exo β-(1,2)-arabinofuranosidase (non-reducing end); cf. EC 3.2.1.226, D-arabinan endo α-(1,5)-arabinofuranosidase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Al-Jourani, O., Benedict, S.T., Ross, J., Layton, A.J., van der Peet, P., Marando, V.M., Bailey, N.P., Heunis, T., Manion, J., Mensitieri, F., Franklin, A., Abellon-Ruiz, J., Oram, S.L., Parsons, L., Cartmell, A., Wright, G.SA., Basle, A., Trost, M., Henrissat, B., Munoz-Munoz, J., Hirt, R.P., Kiessling, L.L., Lovering, A.L., Williams, S.J., Lowe, E.C. and Moynihan, P.J. Identification of D-arabinan-degrading enzymes in mycobacteria. Nat. Commun. 14 (2023) 2233. [PMID: 37076525]
2. Shimokawa, M., Ishiwata, A., Kashima, T., Nakashima, C., Li, J., Fukushima, R., Sawai, N., Nakamori, M., Tanaka, Y., Kudo, A., Morikami, S., Iwanaga, N., Akai, G., Shimizu, N., Arakawa, T., Yamada, C., Kitahara, K., Tanaka, K., Ito, Y., Fushinobu, S. and Fujita, K. Identification and characterization of endo-α-, exo-α-, and exo-β-D-arabinofuranosidases degrading lipoarabinomannan and arabinogalactan of mycobacteria. Nat. Commun. 14 (2023) 5803. [PMID: 37726269]