IUBMB Enzyme Nomenclature


Accepted name: 2,4-dinitroanisole O-demethylase

Reaction: 2,4-dinitroanisole + H2O = methanol + 2,4-dinitrophenol

Glossary: 2,4-dinitroanisole = 1-methoxy-2,4-dinitrobenzene

Other name(s): 2,4-dinitroanisole ether hydrolase; dnhA (gene name); dnhB (gene name); DNAN demethylase

Systematic name: 2,4-dinitroanisole methanol hydrolase

Comments: The enzyme, characterized from the bacterium Nocardioides sp. JS1661, is involved in the degradation of 2,4-dinitroanisole. Unlike other known O-demethylases, such as EC, 4-methoxybenzoate monooxygenase (O-demethylating), or EC, codeine 3-O-demethylase, it does not require oxygen or electron donors, and produces methanol rather than formaldehyde.


1. Fida, T.T., Palamuru, S., Pandey, G. and Spain, J.C. Aerobic biodegradation of 2,4-dinitroanisole by Nocardioides sp. strain JS1661. Appl. Environ. Microbiol. 80 (2014) 7725-7731. [PMID: 25281383]

[EC created 2015]

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