IUBMB Enzyme Nomenclature

EC 3.4.24.45

Accepted name: atrolysin F

Reaction: Cleavage of Val²Asn, Gln⁴His, Leu⁶Cys, His¹⁰Leu, Ala¹⁴Leu and Tyr¹⁶Leu bonds in insulin B chain

Other names: Crotalus atrox metalloendopeptidase; hemorrhagic toxin f; Crotalus atrox metalloendopeptidase f

Comments: A 64 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests the γ chain of fibrinogen. Immunologically distinct from EC 3.4.24.1, atrolysin A.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 172306-52-4

References:

1. Nikai, T., Mori, N., Kishida, M., Sugihara, H. and Tu, A.T. Isolation and biochemical characterization of hemorrhagic toxin f from the venom of Crotalus atrox (western diamondback rattlesnake). Arch. Biochem. Biophys. 231 (1984) 309-319. [PMID: 6375570]

[EC 3.4.24.45 created 1992]

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