IUBMB Enzyme Nomenclature


Accepted name: γ-glutamylanilide hydrolase

Reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline

Glossary: γ-glutamylanilide = N5-phenyl-L-glutamine

Other name(s): atdA2 (gene name)

Systematic name: N5-phenyl-L-glutamine amidohydrolase

Comments: The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the opposite reaction from that catalysed by EC, γ-glutamylanilide synthase, which is part of an aniline degradation pathway. Its purpose is likely to maintain a low concentration of N5-phenyl-L-glutamine, which is potentially toxic.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Takeo, M., Ohara, A., Sakae, S., Okamoto, Y., Kitamura, C., Kato, D. and Negoro, S. Function of a glutamine synthetase-like protein in bacterial aniline oxidation via γ-glutamylanilide. J. Bacteriol. 195 (2013) 4406-4414. [PMID: 23893114]

[EC created 2016]

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