Reaction: (1) AMP + H2O = IMP + NH3
(2) ADP + H2O = IDP + NH3
(3) ATP + H2O = ITP + NH3
Glossary: IMP = inosine 5'-phosphate
AMP = adenosine 5'-phosphate
Other name(s): adenylate deaminase; adenine nucleotide deaminase; adenosine (phosphate) deaminase
Systematic name: adenosine-phosphate aminohydrolase
Comments: Acts on AMP, ADP, ATP, NAD+ and adenosine, in decreasing order of activity. The bacterial enzyme can also accept the deoxy derivatives. cf. EC 3.5.4.6, AMP deaminase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37289-20-6
References:
1. Su, J.-C., Li, C.-C. and Ting, C.C. A new adenylate deaminase from red marine alga Porphyra crispata. Biochemistry 5 (1966) 536-543. [PMID: 5940938]
2. Yates, M.G. A non-specific adenine nucleotide deaminase from Desulfovibrio desulfuricans. Biochim. Biophys. Acta 171 (1969) 299-310. [PMID: 5773435]