Reaction: AMP + H2O = IMP + NH3
For diagram click here.
Other name(s): adenylic acid deaminase; AMP aminase; adenylic deaminase; adenylate deaminase; 5-AMP deaminase; adenosine 5-monophosphate deaminase; 5-adenylate deaminase; adenyl deaminase; 5-adenylic acid deaminase; adenosine monophosphate deaminase; adenylate aminohydrolase; adenylate desaminase; adenosine 5-phosphate aminohydrolase; 5-adenylate deaminase
Systematic name: AMP aminohydrolase
Comments: cf. EC 3.5.4.17 adenosine-phosphate deaminase.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9025-10-9
References:
1. Kalckar, H.M. Differential spectrophotometry of purine compounds by means of specific enzymes. III. Studies of the enzymes of purine metabolism. J. Biol. Chem. 167 (1947) 461-475.
2. Lee, Y.-P. 5'-Adenylic acid deaminase. I. Isolation of the crystalline enzyme from rabbit skeletal muscle. J. Biol. Chem. 227 (1957) 987-992.
3. Lee, Y.-P. 5'-Adenylic acid deaminase. II. Homogeneity and physicochemical properties. J. Biol. Chem. 227 (1957) 993-998.
4. Lee, Y.-P. 5'-Adenylic acid deaminase. III. Properties and kinetic studies. J. Biol. Chem. 227 (1957) 999-1007.
5. Mendicino, J. and Muntz, J.A. The activating effect of adenosine triphosphate on brain adenylic deaminase. J. Biol. Chem. 233 (1958) 178-183.
6. Turner, D.H. and Turner, J.F. Adenylic deaminase of pea seeds. Biochem. J. 79 (1961) 143-147.
7. Weil-Malherbe, W. and Green, R.H. Ammonia formation in brain. 2. Brain adenylic deaminase. Biochem. J. 61 (1955) 218-224.