IUBMB Enzyme Nomenclature


Accepted name: phosphoribosyl-ATP diphosphatase

Reaction: 1-(5-phospho-β-D-ribosyl)-ATP + H2O = 1-(5-phospho-β-D-ribosyl)-AMP + diphosphate

For diagram click here.

Other name(s): phosphoribosyl-ATP pyrophosphatase; phosphoribosyladenosine triphosphate pyrophosphatase; 1-(5-phosphoribosyl)-ATP diphosphohydrolase

Systematic name: 1-(5-phospho-β-D-ribosyl)-ATP diphosphohydrolase

Comments: The Neurospora crassa enzyme also catalyses the reactions of EC (histidinol dehydrogenase) and EC (phosphoribosyl-AMP cyclohydrolase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 69553-55-5


1. Smith, D.W.E. and Ames, B.N. Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis.J. Biol. Chem. 240 (1965) 3056-3063.

[EC created 1981]

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