IUBMB Enzyme Nomenclature


Accepted name: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)

Reaction: 3D-3,5/4-trihydroxycyclohexa-1,2-dione + H2O = 5-deoxy-D-glucuronate

For diagram of reaction click here.

Glossary: 3D-3,5/4-trihydroxycyclohexa-1,2-dione = (3R,4S,5R)-3,4,5-trihydroxycyclohexane-1,2-dione

Other name(s): IolD; THcHDO hydrolase; 3D-3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (decyclizing); 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)

Systematic name: 3D-3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (ring-opening)

Comments: The enzyme, found in the bacterium Bacillus subtilis, is part of the myo-inositol degradation pathway leading to acetyl-CoA.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Yoshida, K., Yamaguchi, M., Morinaga, T., Kinehara, M., Ikeuchi, M., Ashida, H. and Fujita, Y. myo-Inositol catabolism in Bacillus subtilis. J. Biol. Chem. 283 (2008) 10415-10424. [PMID: 18310071]

[EC created 2014]

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