IUBMB Enzyme Nomenclature


Accepted name: 2-haloacid dehalogenase (configuration-retaining)

Reaction: (1) (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide
(2) (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide

Other name(s): 2-haloalkanoic acid dehalogenase; 2-haloalkanoid acid halidohydrolase; DL-2-haloacid dehalogenase; DL-DEXr

Systematic name: (S)-2-haloacid dehalogenase (configuration-retaining)

Comments: Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids, respectively, with retention of configuration at C-2. [See also EC (S)-2-haloacid dehalogenase, EC (R)-2-haloacid dehalogenase and EC 2-haloacid dehalogenase (configuration-inverting)]

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Weightman, A.J., Weightman, A.L. and Slater, J.H. Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas P3: evidence for two different dehalogenation mechanisms. J. Gen. Microbiol. 128 (1982) 1755-1762. [PMID: 7142958]

2. Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N. Bacterial 2-haloacid dehalogenases: Structures and catalytic properties. Pure Appl. Chem. 68 (1996) 2097-2103.

[EC created 2003]

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