IUBMB Enzyme Nomenclature


Accepted name: (S)-2-haloacid dehalogenase

Reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide

For diagram click here.

Other name(s): 2-haloacid dehalogenase[ambiguous]; 2-haloacid halidohydrolase [ambiguous][ambiguous]; 2-haloalkanoic acid dehalogenase; 2-haloalkanoid acid halidohydrolase; 2-halocarboxylic acid dehalogenase II; DL-2-haloacid dehalogenase[ambiguous]; L-2-haloacid dehalogenase; L-DEX

Systematic name: (S)-2-haloacid halidohydrolase

Comments: Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2. [See also EC (R)-2-haloacid dehalogenase, EC 2-haloacid dehalogenase (configuration-inverting) and EC 2-haloacid dehalogenase (configuration-retaining)]

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 37289-39-7


1. Goldman, P., Milne, G.W.A. and Keister, D.B. Carbon-halogen bond cleavage. 3. Studies on bacterial halidohyrolases. J. Biol. Chem. 243 (1968) 428-434. [PMID: 5635785]

2. Motosugi, M., Esaki, N. and Soda, K. Preparation and properties of 2-halo acid dehalogenase from Pseudomonas putida. Agric. Biol. Chem. 46 (1982) 837-838.

3. Klages, M., Krauss, S. and Lingens, F. 2-Haloacid dehalogenase from a 4-chlorobenzoate-degrading Pseudomonas spec. CBS 3. Hoppe-Seyler's Z. Physiol. Chem. 364 (1983) 529-535. [PMID: 6873881]

4. Diez, A., Prieto, M.I., Alvarez, M.J., Bautista, J.M., Garrido, J. and Puyet, A. Improved catalytic performance of a 2-haloacid dehalogenase from Azotobacter sp. by ion-exchange immobilisation. Biochem. Biophys. Res. Commun. 220 (1996) 828-833. [PMID: 8607850]

5. Mörsberger, F.-M., Müller, R., Otto, M.K., Lingens, F. and Kulbe, K.D. Purification and characterization of 2-halocarboxylic acid dehalogenase II from Pseudomonas spec. CBS 3. Biol. Chem. Hoppe-Seyler 372 (1991) 915-922. [PMID: 1772590]

6. Köhler, R., Brokamp, A., Schwarze, R., Reiting, R.H. and Schmidt, F.R.J. Characteristics and DNA-sequence of a cryptic haloalkanoic acid dehalogenase from Agrobacterium tumefaciens RS5. Curr. Microbiol. 36 (1998) 96-101. [PMID: 9425247]

7. Motosugi, K., Esahi, N. and Soda, K. Bacterial assimilation of D- and L-2-chloropropionates and occurrence of a new dehalogenase. Arch. Microbiol. 131, (1982) 179-183. [PMID: 7103659]

8. Kurihara, T., Esaki, N. and Soda, K. Bacterial 2-haloacid dehalogenases: structures and reaction mechanisms. J. Mol. Catal., B Enzym. 10, (2000) 57-65.

9. Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N. Bacterial 2-haloacid dehalogenases: Structures and catalytic properties. Pure Appl. Chem. 68, (1996) 2097-2103.

[EC created 1972, modified 2003]

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