IUBMB Enzyme Nomenclature


Accepted name: oxaloacetate decarboxylase

Reaction: oxaloacetate = pyruvate + CO2

Other name(s): oxaloacetate β-decarboxylase; oxalacetic acid decarboxylase; oxalate β-decarboxylase; oxaloacetate carboxy-lyase

Systematic name: oxaloacetate carboxy-lyase (pyruvate-forming)

Comments: Requires a divalent metal cation. The enzymes from the fish Gadus morhua (Atlantic code) and the bacterium Micrococcus luteus prefer Mn2+, while those from the bacteria Pseudomonas putida and Pseudomonas aeruginosa prefer Mg2+. Unlike EC [oxaloacetate decarboxylase (Na+ extruding)], there is no evidence of the enzyme's involvement in Na+ transport.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Schmitt, A., Bottke, I. and Siebert, G. Eigenschaften einer Oxaloacetat-Decarboxylase aus Dorschmuskulatur. Hoppe-Seyler's Z. Physiol. Chem. 347 (1966) 18-34. [PMID: 5972993]

2. Herbert, D. Oxalacetic carboxylase of Micrococcus lysodeikticus. Methods Enzymol. 1 (1955) 753-757.

3. Horton, A.A. and Kornberg, H.L. Oxaloacetate 4-carboxy-lyase from Pseudomonas ovalis chester. Biochim. Biophys. Acta 89 (1964) 381-383. [PMID: 14205502]

4. Sender, P.D., Martin, M.G., Peiru, S. and Magni, C. Characterization of an oxaloacetate decarboxylase that belongs to the malic enzyme family. FEBS Lett. 570 (2004) 217-222. [PMID: 15251467]

5. Narayanan, B.C., Niu, W., Han, Y., Zou, J., Mariano, P.S., Dunaway-Mariano, D. and Herzberg, O. Structure and function of PA4872 from Pseudomonas aeruginosa, a novel class of oxaloacetate decarboxylase from the PEP mutase/isocitrate lyase superfamily. Biochemistry 47 (2008) 167-182. [PMID: 18081320]

[EC created 1961 as EC, modified 1986, modified 2000, part transferred 2018 to EC]

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