IUBMB Enzyme Nomenclature


Accepted name: oxaloacetate decarboxylase (Na+ extruding)

Reaction: oxaloacetate + 2 Na+[side 1] = pyruvate + CO2 + 2 Na+[side 2]

Other name(s): oxaloacetate β-decarboxylase (ambiguous); oxalacetic acid decarboxylase (ambiguous); oxalate β-decarboxylase (ambiguous); oxaloacetate carboxy-lyase (ambiguous)

Systematic name: oxaloacetate carboxy-lyase (pyruvate-forming; Na+-extruding)

Comments: The enzyme from the bacterium Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn2+. Differs from EC (oxaloacetate decarboxylase) for which there is no evidence for involvement in Na+ transport.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Dimroth, P. Characterization of a membrane-bound biotin-containing enzyme: oxaloacetate decarboxylase from Klebsiella aerogenes. Eur. J. Biochem. 115 (1981) 353-358. [PMID: 7016536]

2. Dimroth, P. The role of biotin and sodium in the decarboxylation of oxaloacetate by the membrane-bound oxaloacetate decarboxylase from Klebsiella aerogenes. Eur. J. Biochem. 121 (1982) 435-441. [PMID: 7037395]

[EC created 1961 as EC, modified 1986, modified 2000, transferred 2018 to EC]

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