IUBMB Enzyme Nomenclature


Accepted name: 2-oxoglutarate decarboxylase

Reaction: 2-oxoglutarate = succinate semialdehyde + CO2

For diagram of reaction click here.

Glossary: thiamine diphosphate

Other name(s): oxoglutarate decarboxylase; α-ketoglutarate decarboxylase; α-ketoglutaric decarboxylase; oxoglutarate decarboxylase; pre-2-oxoglutarate decarboxylase; 2-oxoglutarate carboxy-lyase

Systematic name: 2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)

Comments: Requires thiamine diphosphate. Highly specific.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37205-42-8


1. Shigeoka, S., Onishi, T., Maeda, K., Nakano, Y. and Kitaoka, S. Occurrence of thiamin pyrophosphate-dependent 2-oxoglutarate decarboxylase in mitochondria of Euglena gracilis. FEBS Lett. 195 (1986) 43-47.

[EC created 1989]

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