IUBMB Enzyme Nomenclature


Accepted name: phosphomevalonate decarboxylase

Reaction: ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2

For diagram of reaction click here

Systematic name: ATP:(R)-5-phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)

Comments: The enzyme participates in a mevalonate pathway that occurs in halophilic archaea. The activity is also present in eubacteria of the Chloroflexi phylum. cf. EC, diphosphomevalonate decarboxylase, and EC, bisphosphomevalonate decarboxylase.

Comments: The enzyme participates in a mevalonate pathway that occurs in archaea other than the extreme acidophiles of the Thermoplasmatales order. cf. EC, bisphosphomevalonate decarboxylase

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Dellas, N., Thomas, S.T., Manning, G. and Noel, J.P. Discovery of a metabolic alternative to the classical mevalonate pathway. Elife 2 (2013) e00672. [PMID: 24327557]

2. Vannice, J.C., Skaff, D.A., Keightley, A., Addo, J.K., Wyckoff, G.J. and Miziorko, H.M. Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway. J. Bacteriol. 196 (2014) 1055-1063. [PMID: 24375100]

3. Thomas, S.T., Louie, G.V., Lubin, J.W., Lundblad, V. and Noel, J.P. Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase. ACS Chem. Biol. 14 (2019) 1767-1779. [PMID: 31268677]

[EC created 2014, modified 2018]

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