IUBMB Enzyme Nomenclature


Accepted name: cyclohexa-1,5-dienecarbonyl-CoA hydratase

Reaction: 6-hydroxycyclohex-1-ene-1-carbonyl-CoA = cyclohexa-1,5-diene-1-carbonyl-CoA + H2O

For diagram of reaction click here.

Other name(s): cyclohexa-1,5-diene-1-carbonyl-CoA hydratase; dienoyl-CoA hydratase; cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect)

Systematic name: 6-hydroxycyclohex-1-enecarbonyl-CoA hydro-lyase (cyclohexa-1,5-diene-1-carbonyl-CoA-forming)

Comments: Forms part of the anaerobic benzoate degradation pathway, which also includes EC (glutaryl-CoA dehydrogenase), EC (benzoyl-CoA reductase) and EC (3-hydroyxbutyryl-CoA dehydratase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 214355-79-0


1. Laempe, D., Eisenreich, W., Bacher, A. and Fuchs, G. Cyclohexa-1,5-diene-1-carboxyl-CoA hydratase, an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica. Eur. J. Biochem. 255 (1998) 618-627. [PMID: 9738901] [Erratum Eur. J. Biochem. 257 (1998) 528 only]

2. Harwood, C.S. and Gibson, J. Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes? J. Bacteriol. 179 (1997) 301-309. [PMID: 8990279]

3. Koch, J., Eisenreich, W., Bacher, A. and Fuchs, G. Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism. Eur. J. Biochem. 211 (1993) 649-661. [PMID: 8436125]

[EC created 2000, modified 2001]

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