IUBMB Enzyme Nomenclature


Accepted name: 3-methylfumaryl-CoA hydratase

Reaction: (S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O

For diagram of reaction click here.

Glossary: (S)-citramalyl-CoA = (3S)-3-carboxy-3-hydroxybutanoyl-CoA
3-methylfumaryl-CoA = (E)-3-carboxybut-2-enoyl-CoA

Other name(s): Meh; mesaconyl-C4-CoA hydratase; mesaconyl-coenzyme A hydratase (ambiguous)

Systematic name: (S)-citramalyl-CoA hydro-lyase (3-methylfumaryl-CoA-forming)

Comments: The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Zarzycki, J., Brecht, V., Muller, M. and Fuchs, G. Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus. Proc. Natl. Acad. Sci. USA 106 (2009) 21317-21322. [PMID: 19955419]

[EC created 2014]

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